hrp0097fc6.3 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Is the 24-hour urinary gonadotropin assay an effective diagnostic tool in central precocious puberty? A retrospective study of threshold setting and validation in two cohorts.

Janot Clément , Perrin Pauline , Bretones Patricia , Malburet-Testori Sarah , Perge Kevin , Raverot Véronique , Robert Zoé , Roucher-Boulez Florence , Villanueva Carine , Nicolino Marc , Plotton Ingrid

Background and Aims: Central Precocious Puberty (CPP) caused by the early activation of the hypothalamic-pituitary-gonadal axis is a rare affection that occurs in 0.2% in girls. Clinical signs are suggestive and LHRH-test could be sometimes difficult to use and not always contributive. Gonadotropin assay in twenty-four hours-urinary collection could be an interesting option. The present work intended to evaluate the diagnostic interest of 24-hour urinary gonad...